Lost Girl focuses on the gorgeous and charismatic Bo, a supernatural being called a succubus who feeds on the energy of humans, sometimes with fatal results. Refusing to embrace her supernatural clan system and its rigid hierarchy, Bo is a renegade who takes up the fight for the underdog while searching for the truth about her own mysterious origins.

Three assassins deal with life, love, addiction and trust as each tries to find the answers to a better life. Together, they prove to be the most trustworthy in this tangled web of murder, greed, friendship and betrayal.